Adriana La Volpe is a researcher and group leader at the Institute. For most of his career senior who has been interested in the stability of the genome, a key issue in biology with implications for genome evolution, fertility and oncogenesis. Between 1988 and 1994 describe the genomic organization of repetitive sequence in the Caenorhabditis elegans model organism, with special attention to your organization's origin, evolution and chromosomal. These studies also lead to some reflections on the mechanisms of gene conversion, transposition, and distribution throughout the genome cross-overs. She was the first to identify and describe the roles in meiosis and in the soma of the recombinase RAD-51 in C. elegans and tools provided for the analysis of meiotic progression in oogenesis (1998-2003). Essential gene functions as ERM-11, msh-4, SYP-2 were analyzed in these studies. Recently described the action of genes BRC-1 and FCD-2 (human BRCA1 respectively hortologs and FANCD2 in C. elegans) highlight unknown aspects of cancer-prone genes for example.
